Smart delivery system for the treatment of Alzheimer's disease using nanocouriers


Abstract:
Major outbreak of nanomaterial applications in drug delivery was crucially identified in this era of science. One such applied concept of nanotechnology is evolved as nanocouriers (version of transfersomes™), which ultimately targets the diseases, such as Alzheimer's, Parkinson's, etc. Alzheimer's disease is the primary cause of dementing disorder worldwide. There are many approaches that have been developed for combating this disease but still there is lack of effective curative measure due to several parameters, such as delivery route and blood brain barrier crossing. Development of the transdermal patches has been a major milestone to effectively transport the acetylcholinesterase inhibitor drug across the transdermic barriers. Nanocouriers are the ultra-deformable vesicles that can permeate through the stratum corneum layer of the skin and enhance the availability of the drug to the target sites. Self-assembled nanocouriers were prepared by hand shaking method, and rivastigmine (acetylcholinesterase inhibitor) was encapsulated. Drug entrapment ratio was evaluated and characterised by SEM, FTIR and Zeta potential to understand the shape, size, and potential features. Transdermal drug delivery using nanocouriers can also effectively bypass the first-pass metabolism, with the entrapping efficiency that is more than 90% of drugs and has shown efficient penetration of the drug under in vitro analysis. The size and shape were shown to be consistent around 60 nm and the potential was of neutral charge that was highly stable. Our research was aimed at developing the nano smart patches for efficient delivery process through transdermal layer, which can avoid the care takers for Alzheimer's patients because they could provide a continuous and regulated delivery of the drug.

Keywords:
Transdermal patch; Nanocouriers; First-pass metabolism; Bio-availability

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How to cite this article:
Vinnie Cheeran, Baskar Viswanathan. Smart delivery system for the treatment of Alzheimer's disease using nanocouriers. Journal of Biological and Information Sciences. 2013. 2 (3). 16-20.
Available from: http://archive.biolim.org/jbis/read/BOJ001A0020.