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Evaluating the SLN loaded with amoxicillin for sustained drug release and enhanced bio-availability


Abstract:
The nature of nanomaterials being applied as novel drug delivery systems and their several other advancements, such as patience compliances and increased drug penetration through the absorption barriers have promoted the scientists to work on various nanovehicles. Such potential vehicles effectively behave as biodegradable materials; hence, the solid lipid nanoparticles (SLN) are being focused nowadays to address the problem with several antibiotics that are practiced these days. Amoxicillin is used as an antibacterial drug, which is hydrophilic in nature with poor bio-availability, permeability and absorption as a result of enzymatic degradation. Few antibiotics were randomly chosen here and their physicochemical property was validated based on the Lipinski's rule. Poorly absorbed drug, amoxicillin was incorporated into solid lipid nanoparticles synthesised by solvent injection method with the major composition of cholesterol as solid lipid, and Poloxamer 80 - emulsifiers stabilizer and ethanol: chloroform (1:1) as solvents. The synthesised nanoparticles were characterised for particle size, shape, charge and composition. The drug entrapment efficiency and in vitro drug release kinetics were obtained by ultracentrifugation and dialysis membrane system in a magnetic stirrer respectively. The composition of the prepared formulation was studied by Fourier transform infrared spectroscopy (FTIR). Final results were concluded with better bio-availability that was achieved through in vitro study, and the solid lipid nanoparticles' salient features were identified in FTIR spectrum results. Hence, the solid lipid nanoparticles loaded amoxicillin can function as effective vehicles to transport highly water soluble drugs across the barriers. The solvent injection technique has effectively proved to synthesise the high drug entrapped nanovehicles and was capable of providing a sustained delivery of drug.

Keywords:
Solid lipid nanoparticles; Amoxicillin bio-availability; Sustained drug release; Lipinski's rule; Patient compliance

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How to cite this article:
Rathna R, Abinaya N, Baskar V. Evaluating the SLN loaded with amoxicillin for sustained drug release and enhanced bio-availability. Journal of Biological and Information Sciences. 2013. 2 (4). 32-37.
Available from: http://archive.biolim.org/jbis/read/BOJ001A0023.