Transfersome: A better nano drug carrier

Transfersome: A better nano drug carrier
The current spurring interest in nanobiotechnology is towards the use of lipid vesicles for drug delivery. Among such vesicles, the non-toxic, ultra-flexible and deformable type of vesicles are becoming popular and they are referred to as transfersomes. These vesicles unlike the conventional ones, can pass through the spaces that are 5 to 10 times smaller than their own diameter. This squeezable nature upholds transfersomes as one of the most sought after nano drug formulation.

Similar to other lipid vesicles, transfersomes consist of an aqueous core besieged by the lipid bilayer. As a consequence, this structure can accommodate both hydrophobic (between the lipid layers) and hydrophilic drugs (in the aqueous core). Moreover, these vesicles are biodegradable, biocompatible and provide sustained drug release.

Conventional lipid vesicles can only increase the bio-availability of the drug in stratum corneum or the epidermis. On the other hand, transfersomes have the property of ultra-flexibility and deformability instilled in them, owing to which they can travel in between the cells and transport the drug deep into the dermal layer. In addition, transfersomes can retain large volumes of water; thereby, mimicking our skin tissue. The aforementioned nature of these elastic vesicles makes them the ideal nanocarriers for transdermal delivery of drugs.
How to cite this article:
Sruthi S. Transfersome: A better nano drug carrier. BioLim O-Media. 27 January, 2016. 4(1).
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